L-arginine: a therapeutic option for AIDS/HIV infection?
Med Hypotheses 1992 Jul;38(3):236-9 (ISSN: 0306-9877)
Wrightham MN; Cann AJ; Sewell HF Department of Immunology, University
Hospital, Queen's Medical Centre, Nottingham, UK.
Numerous studies implicate cellular immunological effector systems in
the partial containment of virus replication during the early stages of
HIV infection. Immunostimulatory therapeutic regimes designed to enhance
virus clearance are therefore theoretically attractive, but are accompanied
by the risk of concomitant activation of HIV replication. Supra-normal
levels of L-arginine have been shown to induce broad immune stimulation
in vitro and in vivo, but do not increase HIV gene expression in vitro.
These observations, together with the lack of toxicity of this agent,
suggest a novel therapeutic approach to HIV disease.