ALZHEIMER'S DISEASE - THIAMIN, VITAMIN B1
"Thiamine and Alzheimer's Disease: A Pilot Study"
Blass JP, Gleason P, Brush D, et al, Arch Neurol, August, 1988;45:833-835.
Seven females and 4 males who were between 59 and 83 years of
age with Alzheimer's disease participated in a double-blind, placebo-controlled,
crossover study evaluating the effects of 3 g/day of oral thiamin hydrochloride
for 3 months compared with a placebo, 3 times daily. Results showed
that the Mini-Mental State Examination was higher during the 3 months
with 3 g/day of oral thiamin hydrochloride than with the placebo.
These patients were not thiamin deficient in the conventional sense, malnourished