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"Thiamine and Alzheimer's Disease: A Pilot Study"

Blass JP, Gleason P, Brush D, et al, Arch Neurol, August, 1988;45:833-835.

Seven females and 4 males who were between 59 and 83 years of age with Alzheimer's disease participated in a double-blind, placebo-controlled, crossover study evaluating the effects of 3 g/day of oral thiamin hydrochloride for 3 months compared with a placebo, 3 times daily. Results showed that the Mini-Mental State Examination was higher during the 3 months with 3 g/day of oral thiamin hydrochloride than with the placebo. These patients were not thiamin deficient in the conventional sense, malnourished or alcoholics.



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