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ALZHEIMER'S DISEASE AND INOSITOL

"Inositol Treatment of Alzheimer's Disease: A Double-Blind, Cross-Over Placebo Controlled Trial"

Barak, Yoram, et al, Prog. Neuro-Psychopharmacol. and Biological Psychiatry, 1996;20:729-735.

In a double-blind crossover study, inositol at 6 grams per day versus glucose for 1 month each was carried out in 11 Alzheimer's disease patients. There was an overall improvement in the Cognitive Subscale of the Cambridge Mental Disorder of the Elderly Examination (CAMDEX) with inositol but it was not significant. Language and orientation improved significantly more with inositol than the placebo. There were no serious side effects. The authors feel that higher doses of inositol should be studied in Alzheimer's disease patients for longer periods of time.

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