Diabetes
A benfotiamine-vitamin B combination in treatment of diabetic polyneuropathy.
Stracke H; Lindemann A; Federlin K
Exp Clin Endocrinol Diabetes 1996;104(4):311-6
In a double-blind, randomized, controlled study, the effectiveness of
treatment with a combination of Benfotiamine (an Allithiamine, a lipid-soluble
derivative of vitamin B1 with high bioavailability) plus vitamin B6/B12
on objective parameters of neuropathy was studied over a period of 12
weeks on 24 diabetic patients with diabetic polyneuropathy. The results
showed a significant improvement (p = 0.006) of nerve conduction velocity
in the peroneal nerve and a statistical trend toward improvement of the
vibration perception threshold. Long-term observation of 9 patients with
verum over a period of 9 months support the results. Therapy-specific
adverse effects were not seen. The results of this double-blind investigation,
of the long-term observation and of the reports in the literature support
the contention that the neurotropic benfotiamine-vitamin B combination
represents a starting point in the treatment of diabetic polyneuropathy.
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