Lymphocyte subpopulations in children with vitamin D deficient rickets.
Yener E; Coker C; Cura A; Keskinoglu A; Mir S
Acta Paediatr Jpn 1995 Aug;37(4):500-2
Recent studies have shown
1,25(OH)2D3-mediated modulation of the immune system. We examined lymphocyte
subpopulations of 16 children with nutritional rickets. Most of the patients
suffered more frequent infection episodes than the control group of 15
healthy children and low serum levels of 25OHD and 1,25(OH)2D, such as
38.2 +/- 8.6 ng/mL and 15.7 +/- 2.6 pg/mL respectively. This decrease
correlated with a significant decrease in total T lymphocytes and an increase
in B lymphocytes expressing surface IgA, IgM, IgG molecules. These
results suggest that vitamin D plays an important role in the impaired
functions of T lymphocytes which may lead to frequent infection episodes
in nutritional rickets.