Antioxidant status and acute malaria in children in Kampala, Uganda.
Metzger A; Mukasa G; Shankar AH; Ndeezi G; Melikian G; Semba RD
Am J Trop Med Hyg 2001 Aug;65(2):115-9
Although antioxidant status
has been implicated in the pathogenesis of malaria, these factors need
further characterization. A longitudinal study was conducted involving
273 children 1-10 years of age with acute, uncomplicated malaria in Kampala,
Uganda. Plasma vitamin A, carotenoids, and vitamin E were measured at
enrollment and on day 7. Malaria parasitemia was measured at enrollment,
on day 3, and on day 7. Malaria parasitemia had completely cleared in
57.1% and 85.3% of children by day 3 and day 7, respectively. Plasma vitamin
A, alpha-carotene, beta-carotene, lycopene, lutein/zeaxanthin, and vitamin
E were depressed at enrollment and increased by day 7. Multivariate analyses
showed that higher plasma lycopene concentrations at enrollment were associated
with clearance of parasitemia between enrollment and day 3 (odds ratio
= 1.46, 95% confidence interval = 1.07-2.06, per 0.10 micromol/L of lycopene).
This study suggests that children with acute malaria have depressed plasma
concentrations of antioxidants, and that higher plasma lycopene is associated
with more rapid clearance of malaria parasitemia.