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"Effect of Calcium and Vitamin D Supplementation on Bone Density in Men and Women 65 Years of Age or Older"

Dawson-Hughes, Bess, M.D., et al, The New England Journal of Medicine, September 4, 1997;337(10):670-676.

In evaluating 176 men and 213 women 65 years of age or older who took 500 mg of calcium citrate malate plus 700 IU of vitamin D3 as cholecalciferol per day or a placebo, a significant difference was shown between the calcium-vitamin D and placebo groups at all skeletal sites after 1 year. The data were only significant for total-body bone mineral density in the second and third years. Of the 37 individuals who had nonvertebral fractures, 26 were in the placebo group and 11 were in the calcium-vitamin D group. In the calcium-vitamin D group versus the placebo group, there was increased bone density of 0.5% compared to -0.7% in the femoral neck, 2.12% compared to 1.22% in the spine, and a total body increase in bone density of 0.06% versus -1.09%.



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