BONE LOSS, CALCIUM AND VITAMIN D
Dawson-Hughes, Bess, M.D., et al, The New England Journal of Medicine,
September 4, 1997;337(10):670-676.
"Effect of Calcium and Vitamin D Supplementation on Bone Density
in Men and Women 65 Years of Age or Older"
In evaluating 176 men and 213
women 65 years of age or older who took 500 mg of calcium citrate malate
plus 700 IU of vitamin D3 as cholecalciferol per day or a placebo, a significant
difference was shown between the calcium-vitamin D and placebo groups
at all skeletal sites after 1 year. The data were only significant for
total-body bone mineral density in the second and third years. Of the
37 individuals who had nonvertebral fractures, 26 were in the placebo
group and 11 were in the calcium-vitamin D group. In the calcium-vitamin
D group versus the placebo group, there was increased bone density of
0.5% compared to -0.7% in the femoral neck, 2.12% compared to 1.22% in
the spine, and a total body increase in bone density of 0.06% versus -1.09%.