A New Era in Medicine
Matthias Rath M.D.
The Ice Age - Cardiovascular Disease Connection
My discovery of the Ice Age - vitamin deficiency - cardiovascular disease
connection will eventually lead to the eradication of heart attacks,
strokes and related cardiovascular diseases.2,3 Starting 2.5 million
years ago the Ice Ages dramatically influenced the gene pool of the human
race. Blood loss through the vitamin deficient and scorbutic vascular
wall was the greatest threat to the evolutionary survival of man. Inherited
disorders leading to cardiovascular and related diseases became Nature’s
response to protect the vessel wall during thousands of generations of
extreme vitamin deficiency. The Ice Age - Cardiovascular Disease Axiom
says: "Inherited disorders leading to thickening of blood vessel
walls or protecting the vessel wall in another way during vitamin deficiency
originated during the Ice Ages or were greatly favored during that time.
These diseases can be prevented and treated by optimum intake of vitamins,
particularly vitamin C."
The Ice Age - cardiovascular disease connection invalidates the term
disease for heart attacks, strokes and related cardiovascular disorders
and defines them as conditions caused by nutritional deficiencies. The
same is true for many other inherited disorders leading to a general
thickening of body tissues including the walls of the blood vessels.
These disorders also had an evolutionary advantage because they protected
our ancestors from the fatal consequences of vitamin deficiencies. Based
on these discoveries the following disorders could also be eradicated:
diabetes, homocystinuria, Alzheimer’s Disease, Parkinson’s
Disease, cystic fibrosis, muscular dystrophy, lupus erythematodes and
dozens of other diseases. The details of this discovery are discussed
in my new book.
Eradicating Heart Disease
The eradication of heart disease is a realistic goal. Based o the discoveries
above and on growing scientific evidence accumulated over the years I
developed nutritional recommendations for optimum cardiovascular health.
Hundreds of patients are already following these recommendations. Their
amazing testimonials are important elements of the book:
Cessation of angina pectoris within one or two weeks Cessation of irregular
heartbeat (arrhythmia) within days a Cessation of shortness of breath
Increase in physical and mental strength
These effects are achieved by nutritional supplements reversing impaired
blood flow to the heart muscle as well as improving metabolism of millions
of heart cells. The most important among these nutrients are vitamin
C, vitamin E, niacin, lysine, proline, coenzyme Q10, carnitine as well
as certain minerals. Particular emphasis in the book is given to my earlier
discoveries of the therapeutic effect of ascorbate, lysine and related
compounds in neutralizing the risk from lipoproten(a).5 Moreover, a new
therapeutic mechanism is described by which lysine and proline, together
with other essential nutrients, decrease the "atherosclerotic tumor" in
the vascular wall caused by smooth muscle cells. Based on my earlier
discoveries, my former colleague Linus Pauling has gratefully undertaken
the task to document the therapeutic value of lysine in combination with
ascorbate.6,7 In case histories he reported the decrease of angina pectoris
in patients taking five grams and more of vitamin C and lysine for several
months. While these results are encouraging they also show the limitations
of a therapeutic approach based on two components: five to ten times
higher amounts of supplements and a longer time are needed to bring relief
to the patient. The recommendations documented in my new book take nutritional
medicine one step further towards a comprehensive nutritional resupplementation
for optimum cardiovascular health. The immediate and profound health
improvements even in patients with a variety of severe heart conditions
prove these recommendations most effective for the treatment of different
heart diseases and related conditions. These recommendations stand any
comparison with prescription drugs in the therapy of angina pectoris,
arrhythmia, hypertension, heart failure as well as for the prevention
of diabetic vascular disease and other forms of cardiovascular disease.
A Personal Chronology
My earlier publications in the Journal of Orthomolecular Medicine triggered
repeated interest in the history of these discoveries. Thus, a brief
personal chronology may be in order: In 1987, after having discovered
the lipoprotein(a)-vitamin C connection I recommended vitamin C supplementation
to an individual with high lipoprotein(a) levels. This marks the first
therapeutic attempt to lower elevated blood concentrations of this risk
factor by using vitamin C.8,9 During my research project at Hamburg University
I used L-lysine and synthetic lysine analogs to isolate lipoprotein(a)
from blood and from arterial walls. This suggested the therapeutic use
of lysine and synthetic lysine analogs5, a therapeutic technology for
which I recieved patents in the meantime.. In early 1990, after the prominent
role of lipoprotein(a) in human atherosclerosis was established 10, I
came to the United States to work on the physiologic role of lipoprotein(a)
as well as to pursue my earlier therapeutic discoveries. My scientific
discoveries over the year were primarily published in the Journal of
Orthomolecular Medicine and I had generally invited my former colleague
Linus Pauling to join me as co-author. In September 1992 I founded my
own research firm to further promote research and education in nutritional
For the Benefit of Humanity
My discoveries summarized in my new book open the door to eliminate
heart attacks, strokes and dozens of related disorders in future generations
of mankind. While these discoveries are gratifying small steps for an
individual scientist, they could become giant steps in the service of
1. Rath M. (1993) Eradicating heart disease. San Francisco. This book
has now been replaced by "Why Animals Don’t Get Heart Attacks – But
2. Rath, M., Pauling, L. (1992) A unified theory of human
cardiovascular disease leading the way to the abolition of this disease
as a cause for
human mortality. Journal of Orthomolecular Medicine 7: 5-15.7.
3. Rath M. (1992) Solution to the puzzle of human evolution.
Journal of Orthomolecular Medicine 7: 73-80.
4. Rath M. (1992) Reducing the risk for cardiovascular
disease with nutritional supplements. Journal of Orthomolecular Medicine
5. Rath M and Pauling L. (1991) Solution to the puzzle
of human cardiovascular disease: Its primary cause is ascorbate deficiency,
leading to the
deposition of lipoprotein(a) and fibrinogen/fibrin in the vascular
of Orthomolecular Medicine 6: 125-134.
6. Pauling L. (1991) Case report: Lysine/ascorbate-related
amelioration of angina pectoris. Journal of Orthomolecular Medicine 6:
7. McBeath M, Pauling L. (1993) A case history: lysine/ascorbate-related
amelioration of angina pectoris. Journal of Orthomolecular
Medicine 8: 77-78.
8. Rath M and Pauling L. (1990) Hypothesis: Lipoprotein(a)
is a surrogate for ascorbate. Proceedings of the National
9. Rath M. (1992) Lipoprotein-a reduction by ascorbate.
Journal of Orthomolecular Medicine 7: 81-82.
10. Rath M, Niendorf A, Reblin T, Dietel M, Krebber H-J,
and Beisiegel U. (1989) Detection and quantification
of lipoprotein(a) in the
arterial wall of 107 coronary bypass patients. Arteriosclerosis