>> Главная

Biochemical changes in the connective tissue components of malignant tumors and lungs in mice during metastatic spreading and chemotherapy

Vopr Med Khim 1989 Sep-Oct;35(5):30-4    (ISSN: 0042-8809)

Chubinskaia SG; Sevast'ianova NA; Veksler IG; Slutskii LI

The highest content of hydroxyproline, hexuronic acids and hexoses was found in nonmetastatic tumor tissue Ca 755 of mice as compared with metastatic neoplasms carcinoma 3LL and melanoma B-16. Development of melanoma B-16 metastases involved the active lung stromal reaction, while carcinoma 3LL metastatic spreading did not cause any distinct connective tissue reactions in lungs . Non-toxic doses of drugs, operating via dissimilar mechanisms (cyclophosphane, trielin, parmidine), resulted in similar alterations of the connective tissue components studied in primary tumors of both carcinoma 3LL and melanoma B-16. Content of hydroxyproline, hexuronic acids and hexoses was increased in lung tissue of mice with carcinoma 3LL, simultaneously with distinct inhibition of metastases development after administration of these drugs. The chemotherapeutic treatment did not increase the stromal reaction of lungs with metastases of melanoma B-16 and its antimetastatic effect was less distinct as compared with carcinoma 3LL.



Type a keyword and click on the 'Go' button to begin full-text search throughout the site.

 Printer-friendly page

Send page to a friend Send page to a friend

Bookmark this page Bookmark this page

>> Natural Health Care

>> Studies Worldwide

>> "Business With Disease"

>> International Campaign

>> Open Letter Campaign

>> Take Action

>> Features

 © 2019 Dr. Rath Health Foundation Send page to a friend contact Printer-friendly page Help Previous document Top of the page Function not available in this page Back to Homepage