>> Главная

P53 gene of chang-liver cells (Atcc-Ccl13) exposed to aflatoxin B1 (Afb): the effect of lysine on mutation at codon 249 of exon 7.

Afr J Med Med Sci. 1999 Mar-Jun;28(1-2):71-5.

Uwaifo O., Department of Biochemistry, University of Ibadan, Ibadan, Nigeria.

The effect of different regimes of lysine-pre treatment on mutation at the 3rd nucleotide base of codon 249 which is located at the 7th exon of p53 gene of Chang-liver cells (CCIL13) exposed to aflatoxin B1 (AFB1) has been investigated. There is an indication of inhibition of 1 ug/ml AFB1--induced mutation by pretreatment of cells for 72 hr with 5-molar fold lysine equivalent of 1 µg/ml AFB1. 1 µ/g ml AFB1 was the dose at which there was 50% survival among the cells of CC13 in cytotoxicity studies. The results suggest chemo prevention of AFB1 induced mutation at codon 249 locus of Exon 7 in CCL13's p53 gene and by implication, maybe, AFB1-induced primary liver cancer.



Type a keyword and click on the 'Go' button to begin full-text search throughout the site.

 Printer-friendly page

Send page to a friend Send page to a friend

Bookmark this page Bookmark this page

>> Natural Health Care

>> Studies Worldwide

>> "Business With Disease"

>> International Campaign

>> Open Letter Campaign

>> Take Action

>> Features

 © 2019 Dr. Rath Health Foundation Send page to a friend contact Printer-friendly page Help Previous document Top of the page Function not available in this page Back to Homepage