Ascorbic acid inhibits replication and infectivity of
avian RNA tumor virus.
Proc Natl Acad Sci U S A 1980 May;77(5):2711-5 (ISSN: 0027-8424)
Bissell MJ; Hatie C; Farson DA; Schwarz RI; Soo WJ
Ascorbic acid, at nontoxic concentrations, causes a substantial reduction
in the ability of avian tumor viruses to replicate in both primary avian
tendon cells and chicken embryo fibroblasts. The virus-infected cultures
appear to be less transformed in the presence of ascorbic acid by the
criteria of morphology, reduced glucose uptake, and increased collagen
synthesis. The vitamin does not act by altering the susceptibility of
the cells to initial infection and transformation, but instead appears
to interfere with the spread of infection through a reduction in virus
replication and virus infectivity. The effect is reversible and requires
the continuous presence of the vitamin in the culture medium.